Kara and Elizabeth, two missionaries, have their lives turned upside down when they witness the murder of Father Callahan by hired guns from the Miller Colfax Company. While on the run, they stumble onto a cabin where Michael and Anthony live, two retired contract killers. After convincing them in helping them to safety, Elizabeth and Kara find out they are wanted for the very same murder they witnessed. All four are soon met up with Pinkertons who force them to go on the run turning Anthony and Michael’s mission from that of rescue to fighting for their lives.