Jeanne du Barry follows Jeanne Vaubernier (Maïwenn), a working-class woman determined to climb the social ladder, using her charms to escape her impoverished life. Her lover, the Comte du Barry (Melvil Poupaud), wishes to present her to King Louis XV (Johnny Depp) and orchestrates a meeting through the influential Duke of Richelieu (Pierre Richard). The encounter goes far beyond his expectations for it was love at first sight for the King and Jeanne. Through this ravishing courtesan, the king rediscovers his appetite for life and feels he can no longer live without her. Making Jeanne his last official mistress, scandal erupts as no one at Court will accept a girl from the streets into their rarified world.