Yashiro Isana, also known as Shiro, is wanted for a crime he has no recollection of committing. He finds himself being hunted by the groups HOMRA, led by Mikoto Suoh, “The Red King,” and SCEPTER 4, led by Reisi Munakata, “The Blue King.” While on the run, a young man named Kuroh Yatogami helps him. This fated encounter will change Shiro’s life forever.