NURSE JACKIE season four stars Primetime Emmy Award®- winning actress Edie Falco as Jackie Peyton, a strong-willed and brilliant – but very flawed – emergency room nurse. This season, Jackie comes to realize that both karma and sobriety can be a bitch. In addition to finally confronting her addiction, Jackie’s street smarts and sardonic wit are tested even further by an ambitious new hospital administrator (Bobby Cannavale), who’s determined to run a tight ship and keep Jackie in line.