Dr. Shaun Murphy, a young surgeon with autism and savant syndrome, has worked tirelessly to prove to his colleagues that his extraordinary medical gifts will save lives. In the new season, Shaun is now a newlywed and is faced with navigating more uncertainties in life and at St. Bonaventure Hospital. Meanwhile, the rest of the team must also navigate the complexities of their own changing relationships as they continue to deal with life and death situations.