Seeking to arrange the perfect hunt for a group of wealthy associates, media mogul Broddick (Adam Kendrick) imports an 80-foot python. But an accident allows the python to escape, and it begins putting the squeeze on the locals. The snake's trail of carnage leads FBI agent Alan Sharpe (Kirk B.R. Woller) to the underground tunnels of a water treatment plant. He and marine biologist Monica Bonds (Jaime Bergman) enlist a prominent herpetologist (David Hewlett) whose 70-foot Scarlet Queen boa will be outfitted with Monica's tracking system and used to hunt the python. But Broddick's hunters also want to bag it, Monica's equipment goes haywire, and the bodies keep piling up. Things come to a head in a packed dance club where two of nature's most terrifying predators square off in an action-packed battle of fangs.