Sick of It follows Karl Pilkington as a taxi driver who loses his girlfriend then his way in life, and finds himself living with his elderly American auntie. As he struggles to deal with the modern world his closest companion is the voice in his head - a grumpy, misanthropic alter ego who takes the form of his doppelgänger. He's the uncensored version of Karl, who says what he really thinks without the risk of offending others. As Karl attempts to get his life in order and move on, the voice in his head appears to have other ideas.