A growing zombie infection overtakes an isolated university campus. Hoping to stop the spread of the infection and end the zombie plague, a secret government agency is sent in to find "Patient Zero," the original zombie from which the infection started, and create an antidote. Once on campus, agency operatives Nightingale (SAW II's Emmaunelle Vaugier) and Ellis (Ed Quinn), find the entire university has been completely overrun! Immersed in a giant zombie battle, Nightingale and Ellis discover some of heir fellow agents have their own plans for the zombie DNA.