Based on a play by Neil Simon, this comedy concerns Barney Cashman (Alan Arkin), the owner of successful seafood restaurant who is stuck in the depths of a mid-life crisis. Barney's marriage is no longer providing him with a sense of romantic adventure, and when he discovers his mother's apartment is empty one day a week, he decides that a series of extra-marital affairs is just what he needs. However, Barney's career as a spoiler of women quickly proves to be laughably unsuccessful; he's able to lure three different women to his make-shift love nest — Elaine (Sally Kellerman), Bobbi (Paula Prentiss), and Janette (Renee Taylor) — but try as he might, he can't convince any of them to sleep with him, and in the end, Barney has to settle for seducing his wife. Last of the Red Hot Lovers was the fourth of five Neil Simon adaptations that director Gene Saks would bring to the screen; Saks also directed a number of Simon's successes on Broadway.