Frank (Bill Murray "Ocean's Eleven", "Charlie's Angels"), whose body is the "City of Frank" and host to its' inhabitants, falls victim a viral infection. It's up to white blood cell cop Osmosis Jones (Emmy Award winner Chris Rock "Down to Earth", "Lethal Weapon 4"), who patrols the city, to fight against the biological clock and stop the invading virus with the help of a cold tablet named Drix (Emmy Award winner David Hyde Pierce "Chain of Fools", TV's "Frasier"). Directed by the Farrelly brothers ("Me, Myself and Irene", "There's Something About Mary"). Also starring Molly Shannon ("Superstar", "Analyze This") and the voices of Academy Award nominee Laurence Fishburne ("The Matrix", "Othello"), William Shatner ("Star Trek", "Miss Congeniality") and musicians Brandy (TV's "Moesha") and Kid Rock.