Atsuko is a psychiatrist who uses advanced technology to study the human mind. Atsuko has developed a machine that will allow her to enter the dreams of her patients and study their psyches from the inside. Atsuko also does double duty as Paprika, a high-tech detective who uses this new innovation to find out the truth about what the people she's trailing really think. However, Atsuko falls victim to a thief who steals the one-of-a-kind machine, and Paprika sets out to find it as a wave of psychological instability tears through the city.