THE BIG C: hereafter is designed to bring Cathy Jamison’s journey of the past three years in THE BIG C to its final conclusion. With the help of her no-nonsense therapist (guest star Kathy Najimy), Cathy faces the challenges ahead, including reuniting with her estranged father played by Tony® Award-winner Brian Dennehy. Fashion icon Isaac Mizrahi appears in several episodes as himself, playing a mentor to Andrea (Sidibe), who will start fashion design school.