Ethan (Joe Swanberg) is a director who aims to make meaningful art films, but is struggling with a creative slump and disengagement with his work. His girlfriend Claire (Kate Lyn Sheil), is an actress whose career is beginning to take off. She has accepted the lead part in a werewolf movie being directed by talented young horror filmmaker Ben (Ti West). Ethan's depression leads to jealousy over both Claire’s success and her increasingly close relationship with Ben. Ethan decides to retaliate against Claire by casting her best friend Charlie (Amy Seimetz) in a romantic role opposite himself in his new film.