A doctor tries to cure human deformities through DNA splicing, an obsession drawing him into a dark world where he experiments on the patients at Edgewood Asylum. His neglected, pregnant wife Olivia comes to see him one night when she delivers twins – one a beautiful baby girl, the other a deformed creature that defies nature. Twenty-five years later, on a dark road, a van breaks down. Young, beautiful Liz Holliman of the Roslyn Center for the Deaf is traveling with a group of young teens and her driver, an ex-convict. With a flat tire, a storm, and freezing temperatures, they must seek shelter. The group makes their way to an old abandoned building — the Edgewood Asylum. Little do they know what evil awaits them… Featuring horror icon – Michael Berryman (THE HILLS HAVE EYES FRANCHISE, THE DEVIL’S REJECTS)