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Articles

The Dayhoff Atlas: scaling sequence diversity improves protein design 

July 25, 2025

Kevin K. Yang, Sarah Alamdari, Alex J. Lee, Kaeli Kaymak-Loveless, Samir Char, Garyk Brixi, Carles Domingo-Enrich, Chentong Wang, Suyue Lyu, Nicolo Fusi, Philip Rosenfield, Neil Tenenholtz, Ava P. Amini “The body of data available in protein sequences is something fundamentally…

Articles

Lack of children in public medical imaging data points to growing age bias in biomedical AI 

July 17, 2025

Alex Lu, Stan Hua (opens in new tab), Lauren Erdman (opens in new tab) Artificial intelligence (AI) is transforming healthcare with applications from interpreting electronic healthcare records (opens in new tab) to detecting cancer from medical images. We ask: are…

Illustrated headshot of Alex Lu.
Microsoft Research Podcast

Abstracts: Zero-shot models in single-cell biology with Alex Lu 

May 22, 2025 | Gretchen Huizinga and Alex Lu

The emergence of foundation models has sparked interest in applications to single-cell biology, but when tested in zero-shot settings, they underperform compared to simpler methods. Alex Lu shares insights on why more research on AI models is needed in biological…

Articles

Zero-shot evaluation reveals limitations of foundation models in single-cell biology 

May 16, 2025

Philip Rosenfield, Alex X. Lu, Ava P. Amini, Lorin Crawford, Kasia Z. Kedzierska Single-cell foundation models are an exciting paradigm for biologists, as they may accelerate the understanding of complex cell data and reveal previously unknown biology. Single-cell foundation models…

Research Focus -- Week of March 24
Microsoft Research Blog

Research Focus: Week of March 24, 2025 

March 26, 2025

In this issue, we examine a new conversation segmentation method that delivers more coherent and personalized agent conversation, and we review efforts to improve MLLMs’ understanding of geologic maps. Check out the latest research and other updates.

Research Forum | Episode 4 Talk 4 | Kevin Yang
Articles

A generative model of biology for in-silico experimentation and discovery 

September 3, 2024

This talk discusses how deep learning is enabling us to generate novel and useful biomolecules, allowing researchers and practitioners to better understand biology.

In the news | TechCrunch

Microsoft open sources EvoDiff, a novel protein-generating AI 

September 14, 2023

This week, Microsoft introduced a general-purpose framework, EvoDiff, that the company claims can generate “high-fidelity,” “diverse” proteins given a protein sequence. Different from other protein-generating frameworks, EvoDiff doesn’t require any structural information about the target protein, cutting out what’s typically…

Microsoft Research Focus 15 | Week of May 8, 2023
Microsoft Research Blog

Research Focus: Week of May 8, 2023 

May 10, 2023

In this issue: Microsoft researchers win four more awards; AutoRXN automates calculations of molecular systems; LLM accelerator losslessly improves the efficiency of autoregressive decoding; a frequency domain approach to predict power system transients.

In the news | Volastra

Volastra Therapeutics Partners with Microsoft to Advance Metastatic Cancer Research 

April 6, 2021

Collaboration will integrate Microsoft Azure AI and Volastra’s insights into tumor biology to develop machine learning tools to detect drivers of tumor growth and predict metastatic risk.

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